It reduces inflammation created by free radicals and bacteria naturally present in your skin, as you know inflammation is responsible for the appearance of imperfections, so niacinamide is very beneficial for acne prone skin.

Comparing the use of niacinamide and clindamycin in the treatment of acne, the results showed similar efficacy of niacinamide and clindamycin, which is interesting because clindamycin is a really effective treatment for acne, but like any antibiotic, there is a risk of bacterial resistance emerging from the skin.

This risk does not exist, as niacinamide is not an antibiotic. Another published study showed that niacinamide was more effective than clindamycin in treating acne in patients with oily skin, but less effective than patients with dry skin.


Another effect of niacinamide is that it reduces the transfer of melanin from melanocytes to the skin surface. Therefore, it is very useful in the treatment of solar hyperpigmentation, post-acne as well as melasma.

An interesting study compared the effectiveness of niacinamide versus hydroquinone in people with melasma, patients applied hydroquinone to one side of the face and niacinamide to the other, the improvement was similar on both sides of the face but significantly less irritation on the side treated with niacinamide.


One of the effects of niacinamide is that it increases the production of ceramides, which helps strengthen our skin barrier.

In fact, by stimulating the production of ceramides, lipids that form the cement between the cells of the epidermis, the skin is stronger, protected from dehydration and penetration of irritants. Thanks to this phenomenon, it has a moisturizing effect on the skin by increasing water retention at the epidermal level.

Our skin becomes more resistant and more tolerant to other active ingredients such as vitamin C and retinol. This strengthening of the skin barrier makes niacinamide particularly interesting for people with extremely dry skin prone to redness.

Niacinamide: an anti-aging effect

It also has an anti-aging effect by increasing collagen production and reducing the damage caused by UV rays on the skin, research shows that it is especially effective in mature skin.

On the other hand, a study published in Australia in 2017 showed that taking vitamin B3 by mouth can reduce the appearance of a new skin cancer in patients who already have one.

Niacinamide acts as a shield for the skin against the formation of substances that cause collagen destruction when the skin is exposed to UV rays.

The final effect of niacinamide on the skin is that it reduces sebum production, improving the appearance of pores and reducing acne.

If we summarize all the benefits of niacinamide, it is anti-acne, anti-inflammatory, reducing hyperpigmentation, anti-aging and strengthening our skin barrier. So we can understand the great interest in this active ingredient.

Does it have any side effects?

Niacinamide is one of the safest active ingredients, it can even be used by pregnant or breastfeeding women. Most studies have been done with concentrations below 5%, so if you go with a higher concentration you may rarely experience tingling or redness, especially in people with sensitive skin.

If this happens to you, try a product with a lower concentration. However, in the majority of cases, if you experience irritation after adding Niacinamide to your facial routine, I think you are reacting to an adjuvant and not the Niacinamide itself.

The last thing and this is not a side effect, but a downside, Niacinamide takes time to work, it takes much longer to see the first results than with vitamins A or C. So if you don't see any results after 3 days, that's normal, you should give yourself at least 2 months to see results.

It is effective to use products containing low concentrations of niacinamide, knowing that most studies have niacinamide concentrations below 5%.

One of the advantages of niacinamide is being able to combine it with other active ingredients. It reduces these side effects with retinol, as we've seen, it's also very interesting to add it to an anti acne protocol.

Is Niacinamide and Vitamin C possible?

On the other hand, there was an old rumor in an article written here 40 years ago that niacinamide and vitamin C couldn't be combined, but new studies show us that it's quite possible.

Do not hesitate to use it in the area around the eyes, because with the effect of strengthening the skin barrier, the very thin skin around the eyes will tolerate retinoids much better.

Niacinamide: On which skin types is it effective?

Niacinamide for oily skin?

Niacinamide is water soluble, it can be found in serums or lotions, which is very interesting for people with oily skin, they can avoid oily or oily cosmetics. Niacinamide is a great option if you have oily skin because it helps reduce excess oil production, works as an anti-inflammatory, kAlivia el enrojecimiento y las grietas yreduce visiblemente el tamaño de los poros para la piel en general.

¿Niacinamida para pieles sensibles?

Por otro lado, la niacinamida tiene un pH neutro que la hace apta para pieles sensibles. Es muy estable, por lo que se puede encontrar en más de una crema hydratante.

¿Niacinamida para la piel seca?

La piel seca puede beneficiarse de su increíble acción regeneradora, or que la niacinamida ayuda a estimular la producción natural de ceramida (lípidos) de la piel, fortalece la barrera de la piel y reduce la piel seca en general.

Como ves, la nicacinamida puede ser adecuada para todo tipo de pieles, desde las más secashasta las más sensibles, incluidas las pieles problemáticas (eccemas, rosácea, acné, etc.) mejorando la funcilaios flamción barreray